Career Central

We develop novel small molecule inhibitors for EP2 receptor, NOX and MPO enzymes in our laboratory. We conduct SAR-studies on currently identified novel scaffolds (HTS hits) and optimize the leads by testing in various pharmacological assays and animal models of neuroinflammation (Epilepsy and Alzheimers disease) in the lab, and also investigate the compounds pharmaceutical properties to potentially develop into clinical candidates. For this, we anticipate a potential candidate is well versed with medicinal chemistry principles and practices including the below requirements and skill set.

• The candidate must have an M.S. or a Ph.D. degree with a chemistry/medicinal chemistry major.
• The candidate must have prior experience with the design of organic molecules and synthesis of novel organic compounds following known or novel synthetic methods
• The candidate must have experience with the purification of organic compounds, characterization of novel compounds using 1H, 13C NMR, LC-MS, and HPLC.
• The candidate must be able to handle both analytical and preparative HPLC methods.
• The candidate must have good communication skills to present research results in weekly and quarterly laboratory meetings; and prior experience writing monthly progress reports, manuscripts, and patents.
• The candidate must understand the biochemical and biological results to interpret the SAR studies and make use of biological results to redesign the molecules.

JOB DESCRIPTION: Helps design and conduct research within a specified field while receiving advanced training from a designated Principal Investigator to enhance professional skills and research independence needed for pursuit of a career. The specific area of research in which the trainee is mentored is determined by the department and laboratory of the Postdoc. Designs and evaluates experiments. Develops new ideas that promote current research. Prepares and publishes scientific manuscripts under the direction of the Principal Investigator. May be responsible for operation of specific equipment. May teach techniques to others, train, and supervise research staff. Positions are temporary appointments as a research trainee. The initial appointment is for one year, renewal expected if progress is satisfactory and funds are available. Appointments cannot exceed five years.

MINIMUM QUALIFICATIONS: A doctoral degree (PhD) preferably in the Pharmacology and Chemical Biology field. Excellent scientific writing ability and strong oral communication skills. The ability to work effectively and collegially with colleagues. Additional qualifications as specified by the Principal Investigator.

Candidates only with medicinal chemistry experience are encouraged to apply online to include; CV including recent scientific publications, cover letter including career goals (if any). Inquires only to Thota Ganesh at tganesh@emory.edu